Panthers travel to Arizona for Week 2 to face the Cardinals, with fantasy eyes on Bryce Young’s rebound and Kyler Murray’s continued dual-threat ceiling. Young's opener was modest (255 yards, 1 TD, 3 INT combined with subpar red-zone efficiency), while Murray chipped in with meaningful rushing and two passing scores, hinting at a high-upside fantasy slate if passing production follows. Arizona is favored, with a mid-range total that invites upside plays and cautious lenses on Carolina’s skill-position options given injury notes to Renfrow and in-question marks around linemen.

Odds point to a tight-to-wide swing potential; Panthers on the Moneyline offer value, but Arizona’s home-track ATS trend and a defense-oriented approach could cap high-end ceiling outputs. For fantasy, target Murray as a top weekly floor-ceiling asset, consider Young as a volatile-but-bid-for-top-15 upside option, and monitor Renfrow's status for a potential flex play only if active.

Panthers’ Week 2 outlook tightens as injuries hit the trenches. Wharton’s hamstring will sideline him 2-4 weeks, testing interior depth while Nijman’s Week 1 effort underscored protection issues. Renfrow’s rib injury adds another cut to the receiving corps, with Jones II limited and Crumedy/Jaden Crumedy stepping into larger roles. Cam Jackson could push for more snaps behind Wharton, reshaping the Panthers’ front seven against Arizona.

Fantasy angles shift quickly: Renfrow’s status could boost other receivers in a game Carolina leans on quick throws and run game tempo. With the rookie interior guys stepping up, IDP edges may see increased opportunity, and Young’s sophomore season starts under new pressure, raising the stakes for Week 2 projections and DFS lineups.

Tetairoa McMillan is pegged for a breakout rookie season in Carolina, with the bold projection of eclipsing 1,000 receiving yards. Bryce Young’s arrival could unlock a more efficient Panthers passing attack, especially if McMillan and Young click early. With Adam Thielen back in Minnesota and Jalen Coker sidelined, Xavier Legette and Hunter Renfrow stand to shoulder early targets, lifting the ceiling for the Panthers’ aerial game this year.

The Athletic’s Panthers prediction leans on pre-draft chemistry and McMillan’s Wildcats' production to fuel a revamped offense. If Young and McMillan stay on the same page, Carolina could flip from 30th in passing to a more balanced attack, boosting Renfrow and Legette’s fantasy value and giving McMillan a rookie-season ceiling near 1,000 yards.